发明名称 |
NOVEL HETEROPYRROLE ANALOGS ACTING ON CANNABINOID RECEPTORS |
摘要 |
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects disclose hetero pyrrole analogs acting as CB1 and/or CB 1 receptor antagonists, having selectivity for the CB 1 or CB2 receptor, acting as neutral antagonists, acting preferentially on CB 1 receptors located in the peripheral nervous system, and/or acting as nitric oxide donors. Pharmaceutical preparations employing the disclosed analogs and methods of administering therapeutically effective amounts of the disclosed analogs to provide a physiological effect are also disclosed.
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申请公布号 |
US2012046280(A1) |
申请公布日期 |
2012.02.23 |
申请号 |
US200913202499 |
申请日期 |
2009.02.19 |
申请人 |
MAKRIYANNIS ALEXANDROS;VEMURI VENKATA K.;OLSZEWSKA TERESA |
发明人 |
MAKRIYANNIS ALEXANDROS;VEMURI VENKATA K.;OLSZEWSKA TERESA |
分类号 |
A61K31/5377;A61K31/4155;A61K31/454;A61K31/4545;A61K31/541;A61P1/00;A61P1/08;A61P1/10;A61P1/16;A61P3/00;A61P3/04;A61P3/06;A61P3/10;A61P5/48;A61P9/00;A61P11/00;A61P11/06;A61P13/08;A61P15/00;A61P19/00;A61P19/02;A61P25/02;A61P25/06;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/30;A61P25/32;A61P25/34;A61P25/36;A61P29/00;A61P35/00;C07D401/12;C07D401/14;C07D409/12;C07D413/14;C07D417/12;C07D417/14 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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