发明名称 |
METHOD FOR PRODUCING CONJUGATE OF THYROXINE AND ALBUMIN |
摘要 |
It is an object of the present invention to provide a method for producing a conjugate of thyroxine and albumin with higher purity. The present invention provides a method for producing a conjugate of thyroxine and albumin which comprises: step (a) of converting a carboxyl group in thyroxine having a carboxyl group to be linked to albumin into an active ester and allowing the thyroxine to react with albumin, so as to prepare a conjugate of thyroxine and albumin; and step (b) of purifying the conjugate with the use of an acidic mixed aqueous solvent in which the thyroxine having a carboxyl group to be linked to albumin is dissolved but albumin is not precipitated. |
申请公布号 |
US2012046447(A1) |
申请公布日期 |
2012.02.23 |
申请号 |
US201113213585 |
申请日期 |
2011.08.19 |
申请人 |
KASAGI NORIYUKI;MATSUNO TADAHIRO |
发明人 |
KASAGI NORIYUKI;MATSUNO TADAHIRO |
分类号 |
C07K1/107;C07K14/76 |
主分类号 |
C07K1/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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