发明名称 |
COMPOSITIONS AND METHODS FOR INDUCING CANCER CELL DEATH |
摘要 |
<p>Described herein are pharmaceutical compositions including a sugar or mannose analog (e.g., 2-DG) and an inhibitor of at least one of PERK and GCN2 (e.g., an inhibitor of PERK and an inhibitor of GCN2) for treating cancer, and methods of treating cancer in a subject involving administration of these pharmaceutical compositions. Pharmaceutical compositions [or inducing death of cancer cells include a therapeutically effective amount of a pharmaceutical composition including: a pharmaceutically acceptable carrier, a sugar analog in an amount effective for inhibiting the growth of cancer cells, and an inhibitor of at least one of: PERK and GCN2 in an amount effective for blocking phosphorylation of eif2-l"t in the cancer cells, wherein the combined amounts of the sugar analog and the inhibitor of at least one of: PERK and GCN2 are sufficient for inducing death of the cancer cells.</p> |
申请公布号 |
WO2012024234(A1) |
申请公布日期 |
2012.02.23 |
申请号 |
WO2011US47781 |
申请日期 |
2011.08.15 |
申请人 |
UNIVERSITY OF MIAMI;LAMPIDIS, THEODORE;KURTOGLU, METIN |
发明人 |
LAMPIDIS, THEODORE;KURTOGLU, METIN |
分类号 |
G01N33/574 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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