This invention relates to modified double-stranded oligoribonucleic acid (dsRNA) having improved stability in cells and biological fluids, and methods of making and identifying dsRNA having improved stability, and of using the dsRNA to inhibit the expression or function of a target gene.
申请公布号
AU2005247509(B2)
申请公布日期
2012.02.23
申请号
AU20050247509
申请日期
2005.05.27
申请人
ALNYLAM PHARMACEUTICALS, INC.
发明人
VORNLOCHER, HANS-PETER;ROEHL, INGO;ZIMMERMANN, TRACY STAGE;MANOHARAN, MUTHIAH;AKINC, AKIN;HADWIGER, PHILIPP;RAJEEV, KALLANTHOTTATHIL G.