| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide treatment for lesions of pathological angiogenesis, especially tumors, rheumatoid arthritis, diabetic retinopathy, age-related muscular degeneration, and angiomas. <P>SOLUTION: A conjugate is used comprising a molecule that exerts a biocidal or cytotoxic effect on target cells in the lesions and an antibody directed against an extracellular matrix component which is present in such lesions. The antibody can be directed against fibronectin-2 (IL-2), doxorubicin, interleukin-12(IL-12), Interferon-γ (IFN-γ), Tumor Necrosis Factorα (TNFα) or Tissue Factor protein (which can be truncated). <P>COPYRIGHT: (C)2012,JPO&INPIT |
