LRRC42 AS A TARGET GENE FOR CANCER THERAPY AND DIAGNOSIS

摘要

Objective methods for diagnosing or detecting cancer, or determining a predisposition to developing cancer is described herein. In one embodiment, the present invention provides a diagnostic method that utilizes the expression level of LRRC42 as an index of cancer. The present invention further provides methods of screening for therapeutic substances useful in the treatment of LRRC42-associated disease, such as cancer, e.g. lung cancer. The invention further provides methods of inhibiting the cell growth and thus treating or alleviating one or more symptoms of LRRC42-associated diseases. The invention also features double-stranded molecules that inhibit the expression of LRRC42 gene, vectors encoding thereof and compositions containing them.