摘要 |
<p>The present invention pertains to a pharmaceutical composition comprising a recombinant measles virus encoding a suicide gene for use in the treatment of malignant cells with primary or secondary resistances against an oncolytic measles virus without suicide gene activity. Further, the present invention pertains to a recombinant measles virus based on measles vaccine strain Schwarz encoding a suicide gene, which comprises a fusion of a cytosine deaminase, particularly yeast cytosine deaminase, and a uracil phosphoribosyltransferase, particularly yeast uracil phosphoribosyltransferase, to a method and a kit for preparing the recombinant measles virus as claimed herein.</p> |
申请人 |
LAUER, ULRICH M.;BITZER, MICHAEL;LAMPE, JOHANNA;ZIMMERMANN, MARTINA;BERCHTOLD, SUSANNE;LANGE, SEBASTIAN;NEUBERT, WOLFGANG;BOSSOW, SASCHA |
发明人 |
BITZER, MICHAEL;LAMPE, JOHANNA;ZIMMERMANN, MARTINA;BERCHTOLD, SUSANNE;LANGE, SEBASTIAN;NEUBERT, WOLFGANG;BOSSOW, SASCHA |