发明名称 |
PYRIDINE THIO DERIVATIVE, AND PHARMACEUTICAL COMPOSITION WHICH CONTAINS SAME AND HAS ANTI-HELICOBACTER PYLORI ACTION |
摘要 |
Disclosed are a novel pyridine thio derivative, and a pharmaceutical composition using the novel pyridine thio derivative, particularly a pharmaceutical composition having selective antibacterial activity against Helicobacter pylori. Specifically disclosed is a pyridine thio derivative represented by general formula (I) (wherein R 1 and R 2 each represents a hydrogen atom, a C 1-8 alkyl group or the like; R 3 and R 4 each represents a hydrogen atom, a C 1-8 alkyl group or the like; X represents -O-, -S- or the like; Y represents a C 1-12 alkyl group which may be substituted by a substituent or -(R S -O) n -R 6 (wherein R 5 represents a C 1-5 alkylene group; R 6 represents a C 1-8 alkyl group which may be substituted by a substituent, and n represents an integer of 1-10); and Z represents a hydrogen atom or the like), or a pharmacologically acceptable salt thereof. Also specifically disclosed is a pharmaceutical composition containing the pyridine thio derivative or a salt thereof. |
申请公布号 |
EP2420500(A1) |
申请公布日期 |
2012.02.22 |
申请号 |
EP20100761444 |
申请日期 |
2010.04.08 |
申请人 |
ARIGEN PHARMACEUTICALS, INC. |
发明人 |
YAMAMOTO, MASAICHI;ITO, MASAHARU;TSUJII, MASAHIKO;HAMAZAKI, MITSUNORI |
分类号 |
C07D401/12;A61K31/4439;A61P1/04;A61P31/04;A61P35/00 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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