发明名称 |
PROCESS FOR PRODUCING PENTACYCLIC TAXANE |
摘要 |
<p>Taxan derivatives are produced efficiently and inexpensively, which are useful as oral-administrable antitumor compounds. A compound of formula (1) (wherein R 1 is an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group or a heterocyclic group; R 2 is a hydroxyl group optionally having a protective group) is processed with an alkali metal permanganate to produce a compound of formula (2), which may be a starting material for oral-administrable antitumor compounds.</p> |
申请公布号 |
EP1741716(B8) |
申请公布日期 |
2012.02.22 |
申请号 |
EP20050737233 |
申请日期 |
2005.04.27 |
申请人 |
DAIICHI SANKYO COMPANY, LIMITED |
发明人 |
IMURA, AKIHIRO;YAMAGUCHI, TATSUYA;TAKAYANAGI, Y.;UCHIDA, SEISHIRO |
分类号 |
C07D493/04;A61K31/443;A61P35/00;C07D213/61;C07D493/08 |
主分类号 |
C07D493/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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