发明名称 |
DIAGNOSIS AND TREATMENT OF CANCER USING ANTI-TMPRSS11E ANTIBODY |
摘要 |
<p>[Problem to be Solved] An object of the present invention is to provide novel means for the treatment and diagnosis of cancer. [Solution] The present inventors have obtained a monoclonal antibody against TMPRSS11E and found that this antibody binds to a native form of TMPRSS11E, and TMPRSS11E is highly expressed on the cell membranes of cancer cell lines in flow cytometry. This antibody exhibits antibody-dependent cell-mediated cytotoxicity activity (ADCC activity) and antitumor effect based on internalization activity and is promising as a therapeutic target. Moreover, this antibody has neutralization activity against protease activity and is also expected to have effect brought about by the inhibition of TMPRSS11E functions.</p> |
申请公布号 |
EP2420515(A1) |
申请公布日期 |
2012.02.22 |
申请号 |
EP20100764278 |
申请日期 |
2010.04.15 |
申请人 |
THE UNIVERSITY OF TOKYO;FORERUNNER PHARMA RESEARCH CO., LTD. |
发明人 |
ABURATANI, HIROYUKI;ISHIKAWA, SHUNPEI;NAKANO, KIYOTAKA |
分类号 |
C07K16/40;A61K39/395;A61P35/00;C07K16/28;C12N15/09;C12Q1/02;C12Q1/37;C12Q1/68;G01N33/573;G01N33/574 |
主分类号 |
C07K16/40 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|