发明名称 |
Human anti-KIR antibodies |
摘要 |
Compositions and methods for regulating an immune response in a subject are described. More particularly, described are human antibodies that regulate the activity of NK cells and allow a potentiation of NK cell cytotoxicity in mammalian subjects, and antibodies having antigen-binding properties similar to those of human monoclonal antibody 1-7F9 or 1-4F1. Described also are also fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising the same and their uses, particularly for use in therapy, to increase NK cell activity or cytotoxicity in subjects.
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申请公布号 |
US8119775(B2) |
申请公布日期 |
2012.02.21 |
申请号 |
US20080244170 |
申请日期 |
2008.10.02 |
申请人 |
MORETTA ALESSANDRO;DELLA CHIESA MARIELLA;ANDRE PASCALE;GAUTHIER LAURENT;ROMAGNE FRANCOIS;WAGTMANN PETER ANDREAS NICOLAI REUMERT;SVENDSEN IVAN;ZAHN STEFAN;SVENSSON ANDERS;THOROLFSSON MATTHIAS;PADKAER SOEREN BERG;KJAERGAARD KRISTIAN;SPEE PIETER;WILKEN MICHAEL;UNIVERSITY OF GENOA;INNATE PHARMA S.A.S.;NOVO NORDISK A/S |
发明人 |
MORETTA ALESSANDRO;DELLA CHIESA MARIELLA;ANDRE PASCALE;GAUTHIER LAURENT;ROMAGNE FRANCOIS;WAGTMANN PETER ANDREAS NICOLAI REUMERT;SVENDSEN IVAN;ZAHN STEFAN;SVENSSON ANDERS;THOROLFSSON MATTHIAS;PADKAER SOEREN BERG;KJAERGAARD KRISTIAN;SPEE PIETER;WILKEN MICHAEL |
分类号 |
C12P21/08;C07K16/00 |
主分类号 |
C12P21/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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