发明名称 Inhibiting vascularization using antibodies to CXCR4 and SDF-1
摘要 This invention provides a therapeutic agent for inhibiting neovascularization, a therapeutic agent for a solid cancer, a therapeutic agent for a disease pathologically caused by neovascularization, and a therapeutic agent for repairing a tissue comprising as the effective ingredient, a substance that potentiates the action of CXCR4. Based on the finding that vascularization is suppressed in CXCR4 knockout mice, it becomes possible to prepare a therapeutic agent for suppressing vascularization, a therapeutic agent for a solid cancer, a therapeutic agent for a disease pathologically caused by neovascularization, each of which comprises as the effective ingredient, a substance that inhibits the action of CXCR4, as well as to prepare a therapeutic agent for repairing a tissue comprising as the effective ingredient, a substance that potentiates the action of CXCR4. Methods for treatment are made possible that use these therapeutic agents.
申请公布号 US8119126(B2) 申请公布日期 2012.02.21
申请号 US20040785230 申请日期 2004.02.25
申请人 KISHIMOTO TADAMITSU;NAGASAWA TAKASHI;TACHIBANA KAZUNOBU;CHUGAI SEIYAKU KABUSHIKI KASHA;TADAMITSU KISHIMOTO 发明人 KISHIMOTO TADAMITSU;NAGASAWA TAKASHI;TACHIBANA KAZUNOBU
分类号 A61K39/00;A61K38/17;A61K39/395 主分类号 A61K39/00
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