| 发明名称 |
Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators |
| 摘要 |
The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD). In particular, the invention relates to compounds and compositions and the methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the inhibition of malonyl-coenzyme A decarboxylase. |
| 申请公布号 |
US8119819(B2) |
申请公布日期 |
2012.02.21 |
| 申请号 |
US20090431720 |
申请日期 |
2009.04.28 |
| 申请人 |
ARRHENIUS THOMAS;CHEN MI;CHENG JIE FEI;HUANG YUJIN;NADZAN ALEX MICHAEL;PENULIAR RICHARD JULIUS;WALLACE DAVID MARK;ZHANG LIN;LOPASCHUK GARY D.;DYCK JASON R.;CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
ARRHENIUS THOMAS;CHEN MI;CHENG JIE FEI;HUANG YUJIN;NADZAN ALEX MICHAEL;PENULIAR RICHARD JULIUS;WALLACE DAVID MARK;ZHANG LIN;LOPASCHUK GARY D.;DYCK JASON R. |
| 分类号 |
C07D207/30;A61K31/045;A61K31/095;A61K31/133;A61K31/137;A61K31/16;A61K31/165;A61K31/341;A61K31/41;A61K31/415;A61K31/4164;A61K31/42;A61K31/426;A61K31/427;A61K31/433;A61K31/44;A61K31/4439;A61K31/444;A61K31/454;A61K31/505;A61K31/5375;A61K31/55;A61K31/664;A61P3/04;A61P3/10;A61P3/12;A61P9/00;A61P9/04;A61P9/10;A61P35/00;A61P43/00;C07C33/48;C07C215/24;C07C233/22;C07C307/10;C07C323/14;C07D233/54;C07D239/42;C07D261/04;C07D261/08;C07D277/20;C07D277/46;C07D277/48;C07D277/52;C07D285/12;C07D285/135;C07D307/46;C07D401/12;C07D413/04;C07D413/06;C07D413/12;C07D417/12;C07D417/14;C07D487/08;C07D498/08;C07F9/24;C07F9/6539 |
主分类号 |
C07D207/30 |
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