WAY OF BUSERELIN PRODUCTION AND INTERMEDIATE COMPOUNDS FOR ITS PRODUCTION

摘要

FIELD: pharmaceutical chemistry. ^ SUBSTANCE: invention refers to the field of pharmaceutical chemistry, and more precisely to a new way of buserelin production with the formula: pGlu-His-Trp-Ser-Tyr-D-Ser(Bu1)-Leu-Arg-Pro-NH-C2H52AcOH (I) consisting in the fact that the synthesis is performed by means of condensing of C-ended protected dipeptide with the formula: X-pGlu-His-OH (IIa), where X is a protective group, with N-ended protected heptapeptide with the formula: H-Trp-Ser-Tyr-D-Ser(Bu1)-Leu-Arg-Pro-NH-C2H5 (III) and obtained N-protected nonapeptide ethylamide with the formula: X-pGlu-His-Trp-Ser-Tyr-D-Ser(Bu1)-Leu-Arg-Pro-NH-C2H5 (IV) that is treated with an unblocking agent in order to remove the N-protective group, and the end product is extracted with the help of chromatography. ^ EFFECT: way of buserelin production. ^ 4 cl, 9 ex