发明名称 |
USE OF APOPTOSIS INHIBITING COMPOUNDS IN DEGENERATIVE NEUROLOGICAL DISORDERS |
摘要 |
The invention provides methods and compositions for localized delivery of a vector comprising a therapeutic agent to a specific region of the brain associated with a neurodegenerative diseases that is characterized by an excess buildup of buildup of intracellular protein aggregates. In particular, the invention provides methods and compositions used to deliver an adeno-associated virus vector (AAV) comprising a nucleotide sequence encoding an inhibitor of apoptosis protein (IAP) to cells in the region. |
申请公布号 |
US2012039991(A1) |
申请公布日期 |
2012.02.16 |
申请号 |
US201113211832 |
申请日期 |
2011.08.17 |
申请人 |
KAPLITT MICHAEL;MOUSSATOV SERGUEI;NEUROLOGIX, INC. |
发明人 |
KAPLITT MICHAEL;MOUSSATOV SERGUEI |
分类号 |
A61K9/127;A61K31/7088;A61K38/16;A61P25/00;A61P25/16;A61P25/28 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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