T-Helper Cell Type 17 Lineage-Specific Adjuvants, Compositions and Methods

摘要

The present invention relates to compositions and methods for the modulation of TN 17 responses. The invention provides compositions for the induction of TN 17 responses containing a TLR agonist and an apoptotic cell-associated agent or containing a microbe-infected apoptotic cell. The compositions of the present invention may also contain dendritic cells capable inducing TN 17 responses. In other embodiments, the invention provides compositions for the inhibition of TN 17 responses containing one or more blocking agents. Methods and compositions for the modulation of TN 17 responses and for the treatment of TN 17-associated diseases and for cancer are also provided.