发明名称 |
INJECTABLE PHARMACEUTICAL COMPOSITION FOR PREVENTING, STABILISING AND/OR INHIBITING PATHOLOGICAL NEOVASCULARIZATION-RELATED CONDITIONS |
摘要 |
This invention relates to a pharmaceutical composition for the treatment and/or prevention of at least one pathological neovascularization-related conditions of the interior of the eye, the composition comprising a therapeutically effective amount of an antisens oligonucleotide having the sequence SEQ ID NO: 1: 5'-TCTCCGGAGGGCTCGCCATGCTGCT-3' or any function conservative sequence comprising from 9 to 30 nucleotides that has 75%, 80%, 85%, 90%, 95% or more than 95%, 96%, 97%, 98%, 99% of identity compared to SEQ ID NO: 1 and that conserves the capacity of inhibiting IRS-1 gene expression as SEQ ID NO: 1, and the composition being administered within the posterior segment of the eye to a subject in need thereof; this invention also relates to a method for treating a pathological neovascularization-related condition of the interior of the eye in a subject in need thereof comprising administering to the subject a therapeutically effective amount of said pharmaceutical composition.
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申请公布号 |
CA2807858(A1) |
申请公布日期 |
2012.02.16 |
申请号 |
CA20112807858 |
申请日期 |
2011.08.10 |
申请人 |
GENE SIGNAL INTERNATIONAL SA |
发明人 |
AL-MAHMOOD, SALMAN;COLIN, SYLVIE;CONDUZORGUES, JEAN-PASCAL;VIAUD, ERIC |
分类号 |
C12N15/113;A61K31/711;A61P9/00;A61P27/02 |
主分类号 |
C12N15/113 |
代理机构 |
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地址 |
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