STERILIZATION OF DISPERSION OF NANOPARTICULATE ACTIVE AGENT WITH γ RADIATION

摘要

PROBLEM TO BE SOLVED: To provide methods for sterilization of dispersions of one or more nanoparticulate active agents via γ irradiation, and obtainable pharmaceutical compositions.

SOLUTION: A liquid dispersion of at least one active agent poorly soluble in a liquid dispersion medium and having an effective average particle size of less than about 2 μm is provided and sterilized via the γ irradiation of an accumulated dose of 25 kGrey.

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