PURIFIED EMD PROTEIN COMPOSITION

摘要

The present invention relates to an improved pharmaceutical, dental and/or cosmetic composition consisting of purified Enamel Matrix Derivative (EMD) proteins which have a molecular weight between 1 and 55kDa, formulated in a suitable pharmaceutical carrier. The present invention further relates to an improved pharmaceutical, dental and/or cosmetic composition comprising purified Enamel Matrix Derivative (EMD) proteins, which is depleted of proteins which have a molecular weight between 56 and 160kDa and an iso-electric point between 3-10. The improved pharmaceutical, dental and/or cosmetic composition of the present invention comprises purified Enamel Matrix Derivative (EMD) proteins, which are depleted of proteinase inhibitors, such as a1-antichymotrypsin and/or Fetuin A. Said improved composition is herein preferably intended to be used for promoting and/or inducing regeneration of hard tissue, tissue mineralization, bone growth and/or bone regrowth, regeneration of dentin, cementogenesis, and/or binding between parts of living mineralized tissue, for bonding of a piece of living mineralized tissue to a bonding site on a piece of other living tissue, for endorsing binding between hard tissues, and/or for filling a mineralized wound cavity and/or tissue defect following from a procedure and/or trauma.