发明名称 |
CRYSTALLINE FORM OF PYRIMIDIO[6,1-A]ISOQUINOLIN-4-ONE COMPOUND |
摘要 |
The current invention is directed towards a polymorph of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, in the form of a crystalline solid consisting of greater than 99% by weight of N-{2-[(2E)-2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinoIin-3(4H)-yl]ethyl}urea, at least 95% in the polymorphic form of a thermodynamically stable polymorph (I) of N-{2-[(2E)-2-(mesitylimino)-9,10-dimetlioxy-4-oxo-6,7-dihydro-2H-pyrimido[6,1-a]-isoquinolin-3(4H)-yl]ethyl}urea, wherein said polymorph is determined by single crystal X-ray structural analysis and X-ray powder diffraction pattern.
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申请公布号 |
CA2807082(A1) |
申请公布日期 |
2012.02.16 |
申请号 |
CA20112807082 |
申请日期 |
2011.08.09 |
申请人 |
VERONA PHARMA PLC |
发明人 |
WALKER, MICHAEL, J., A.;PLOUVIER, BERTRAND, M., C.;NORTHEN, JULIAN, S.;FERNANDES, PHILIPPE |
分类号 |
C07D471/04;A61K31/519;A61P11/00 |
主分类号 |
C07D471/04 |
代理机构 |
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