The present invention derives from the finding that increased levels of alpha 2a adrenergic receptors (ADRA2a) are associated with chronic liver disease and that by decreasing ADRA2a levels in vivo, a number of symptoms and consequences of chronic liver disease may be reduced. Accordingly, the invention provides ADRA2a antagonists for use in a method of treating an individual suffering from liver disease.
申请公布号
WO2012020235(A1)
申请公布日期
2012.02.16
申请号
WO2011GB01217
申请日期
2011.08.12
申请人
UCL BUSINESS PLC;MOOKERJEE, RAJESHWAR, P.;SHARMA, VIKRAM;JALAN, RAJIV