发明名称 |
THERAPEUTIC AGENT FOR TREATING DISEASES IN WHICH NEOPLASTIC PROLIFERATION OF PLASMA CELLS OCCURS |
摘要 |
The present invention provides a therapeutic agent, for diseases in which neoplastic proliferation of plasma cells occurs, which is characterized by containing an anti-human CD48 monoclonal antibody and having cellular cytotoxicity to cells expressing human CD48; and the monoclonal antibody. In addition, the present invention provides a method for screening an active ingredient of a therapeutic agent for diseases in which neoplastic proliferation of plasma cells occurs, the method including the following processes:
(1) a process of sorting a substance that binds specifically to human CD48; and
(2) a process of sorting a substance having cellular cytotoxicity. |
申请公布号 |
EP2418222(A1) |
申请公布日期 |
2012.02.15 |
申请号 |
EP20100761758 |
申请日期 |
2010.04.09 |
申请人 |
OSAKA UNIVERSITY |
发明人 |
HOSEN, NAOKI;SUGIYAMA, HARUO |
分类号 |
C07K16/28;A61K39/395;A61P35/00;C12P21/08;C12Q1/04;G01N33/15;G01N33/48;G01N33/50;G01N33/53;G01N33/577 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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