发明名称 |
VERFAHREN ZUR IDENTIFIZIERUNG VON AGONISTEN ODER ANTAGONISTEN FÜR DEN G PROTEIN GEKOPPELTEN REZEPTOR ßMAS LIKE 1ß |
摘要 |
Identifying a compound (I) that binds specifically to the G protein-coupled receptor mas-like-1 (R) by (i) treating at least one cell that expresses R on its surface (or a preparation of the cells that contains R) with at least one test compound and (ii) detecting any binding to R. Independent claims are also included for the following: (1) similar methods for identifying compounds that bind specifically to R and are competitive with respect to a first compound, or that bind specifically to R and either activate or inhibit it; (2) pharmaceutical composition containing compounds identified by the new methods; (3) use of substance P (or its cleavage products) or neuropeptide FF (a) for treating diseases associated with defects in R or (b) for preparing a complex with R; and (4) protein that comprises R to which substance P (or its cleavage products) or neuropeptide FF is bound specifically. |
申请公布号 |
AT542141(T) |
申请公布日期 |
2012.02.15 |
申请号 |
AT20030735480T |
申请日期 |
2003.05.28 |
申请人 |
SANOFI-AVENTIS DEUTSCHLAND GMBH |
发明人 |
KOSTENIS, EVI;GASSENHUBER, JOHANN |
分类号 |
G01N33/74;A61K38/17;A61K38/22;A61K45/00;A61P9/00;C07K14/47;C07K14/705;C12N15/09;C12Q1/02;G01N33/15;G01N33/50;G01N33/53;G01N33/566;G01N33/567 |
主分类号 |
G01N33/74 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|