发明名称 |
ANTIMYCOTIC PHARMACEUTICAL COMPOSITION |
摘要 |
In a pharmaceutical composition for external use containing a compound such as luliconazole and/or a salt thereof in an amount of 5% by mass or more, comprised is/are acetone, a polyoxyethylene alkyl (having 8 to 30 carbon atoms) ether, and/or a polyoxyethylene alkenyl (having 8 to 30 carbon atoms) ether. Provided is a preparation using a solvent other than crotamiton, propylene carbonate, and N-methyl-2-pyrrolidone as a solvent for solubilization and steric stabilization and having the following properties: 1) when a compound represented by the general formula (1) and/or a salt thereof has a stereoisomer, the amount of the stereoisomer of the compound and/or a salt thereof produced under a preservation condition of 60° C. for 3 weeks is 1% by mass or less with respect to the total mass of the compound and/or a salt thereof at the beginning of preservation; 2) the preparation is in a clear liquid state when preserved at a constant temperature of 20° C. immediately after manufacture; and 3) no crystal is deposited when the preparation is preserved at 5° C. for 2 weeks after manufacture. |
申请公布号 |
EP2416757(A2) |
申请公布日期 |
2012.02.15 |
申请号 |
EP20100714490 |
申请日期 |
2010.04.09 |
申请人 |
POLA PHARMA INC.;NIHON NOHYAKU CO., LTD. |
发明人 |
KOBAYASHI, HIROKAZU;KOSUGI, EIKO;KUBOTA, NOBUO |
分类号 |
A61K9/08 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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