发明名称 |
Packaging cells for recombinant adenovirus |
摘要 |
In the absence of substantial sequence overlap between a recombinant adenoviral vector and the genome of a packaging cell, helper-dependent E1-containing particles (HDEP) can be formed at low frequency. Provided are means and methods for reducing or preventing the generation of HDEP. To this purpose, novel packaging cells and methods of making these are provided. |
申请公布号 |
US8114637(B2) |
申请公布日期 |
2012.02.14 |
申请号 |
US20100804179 |
申请日期 |
2010.07.14 |
申请人 |
VOGELS RONALD;HAVENGA MENZO JANS EMCO;ZUIJDGEEST DAVID ADRIANUS THEODORUS MARIA;CRUCELL HOLLAND B.V. |
发明人 |
VOGELS RONALD;HAVENGA MENZO JANS EMCO;ZUIJDGEEST DAVID ADRIANUS THEODORUS MARIA |
分类号 |
C12P19/34;A61K48/00;C07K14/075;C12N5/10;C12N7/00;C12N15/861 |
主分类号 |
C12P19/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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