发明名称 |
RNA Interference That Blocks Expression of Pro-Apoptotic Proteins Potentiates Immunity Induced by DNA and Transfected Dendritic Cell Vaccines |
摘要 |
An immunotherapeutic strategy is disclosed that combines antigen-encoding DNA vaccine compositions combined with siRNA directed to pro-apoptotic genes, primarily Bak and Bax, the products of which are known to lead to apoptotic death. Gene gun delivery (particle bombardment) of siRNA specific for Bak and/or Bax to antigen-expressing DCs prolongs the lives of such DCs and lead to enhanced generation of antigen-specific CD8+ T cell-mediated immune responses in vivo. Similarly, antigen-loaded DC's transfected with siRNA targeting Bak and/or Bax serve as improved immunogens and tumor immunotherapeutic agents.
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申请公布号 |
US2008069840(A1) |
申请公布日期 |
2008.03.20 |
申请号 |
US20070773162 |
申请日期 |
2007.07.03 |
申请人 |
WU TZYY-CHOOU;HUNG CHIEN-FU |
发明人 |
WU TZYY-CHOOU;HUNG CHIEN-FU |
分类号 |
A61K39/12;A61K31/7088;A61K39/02;A61K39/245;A61K48/00;A61P35/00;A61P37/00;C12N15/11;C12N15/113 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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