发明名称 |
INDOLINE SCAFFOLD SHP-2 INHIBITORS AND METHOD OF TREATING CANCER |
摘要 |
Protein tyrosine phosphatase (PTP) Shp2 is a non-receptor PTP that involved in cell signaling and regulation of cell proliferation, differentiation, and migration. Shp2 mediates activation of kinases that are involved in the pathogenesis of human carcinoma. A high throughput screen identified compounds that inhibit the PTP Shp2. Several compounds were identified that selectively inhibit Shp2 over Shp1 with low to sub-micromolar activity. Also disclosed are methods of inhibiting a protein tyrosine phosphatase in a cell and treating cancer through selective inhibition of Shp2.
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申请公布号 |
US2012034186(A1) |
申请公布日期 |
2012.02.09 |
申请号 |
US201113274699 |
申请日期 |
2011.10.17 |
申请人 |
WU JIE;LAWRENCE NICHOLAS JAMES;SEBTI SAID M.;LAWRENCE HARSHANI RITHMA;UNIVERSITY OF SOUTH FLORIDA;H. LEE MOFFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. |
发明人 |
WU JIE;LAWRENCE NICHOLAS JAMES;SEBTI SAID M.;LAWRENCE HARSHANI RITHMA |
分类号 |
A61K38/21;A61K31/404;A61K31/497;A61P35/00;C07D209/40;C07D403/04 |
主分类号 |
A61K38/21 |
代理机构 |
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地址 |
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