| 摘要 |
A method for determining multiplex biomarker algorithms based on optical, physical and/or electromagnetic patterns, and applying the multiplex biomarker algorithms so as to provide a single diagnostic result indicative of a medical condition, the method comprising: measuring multiple physical, electromagnetic or optical patterns in the setting of experimentally induced or clinically occurring disease using at least one of physical, electromagnetic and optical sensors; using known mathematical or machine learning algorithms to compile the measured parameters, or their signal transformed versions, into a uniplex scale or index using a clinical classifier, such that the uniplex scale or index has better clinical performance in identifying a medical condition than any of the input parameters individually; optimizing the algorithm iteratively using additional clinical data sets and inputting patient characteristics and laboratory derived measurements; using the uniplex scale or index to identify a medical condition; and displaying to a user the single diagnostic result indicative of a medical condition. |
