MARKERS OF FEBRILE SEIZURES AND TEMPORAL LOBE EPILEPSY

摘要

Described is the use of the Srp9 gene and/or Srp14 gene and/or SRP9 polypeptide and/or SRP14 polypeptide as a diagnostic marker, in particular for febrile seizures, complex febrile seizures, for complex epilepsy syndromes including FS, such as Dravet's syndrome and epilepsies with mental retardation, and/or for temporal lobe epilepsy. Additionally, the genes and/or polypeptides may be used for identifying subjects at risk of developing febrile seizures. The invention further provides for kits for identifying subjects at risk of developing febrile seizures and methods of preventing and/or treating febrile seizures, as well as compounds suitable for these purposes.