发明名称 |
REPROGRAMMING IMMORTALIZED B CELLS |
摘要 |
<p>Methods and composition for providing induced pluripotent stem (iPS) cells are provided. For example, in certain aspects methods including reprogramming B lymphocytes transformed by episomal vectors such as Epstein-Barr virus-based vectors are described. Furthermore, the invention provides induced pluripotent stem cells essentially free of exogenous elements and having B cell immunoglobin variable region rearrangement.</p> |
申请公布号 |
CA2806858(A1) |
申请公布日期 |
2012.02.09 |
申请号 |
CA20112806858 |
申请日期 |
2011.08.03 |
申请人 |
CELLULAR DYNAMICS INTERNATIONAL, INC. |
发明人 |
THOMSON, JAMES;RAJESH, DEEPIKA;DICKERSON, SARAH JANE;MACK, AMANDA;MILLER, MICHAEL |
分类号 |
C12N5/074;C12N5/0781;C12N5/10;C12N15/33 |
主分类号 |
C12N5/074 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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