摘要 |
This invention provides methods for reducing the extent and progression of traumatic brain injury and its deleterious sequellae specifically cognitive decline, post-traumatic epilepsy, post-traumatic stress disorder, and other adverse consequences depending on the progression of the initial injury, comprising administering to a TBI victim in need thereof a therapeutically-effective amount of an antiglycolytic compound, particularly 2-deoxyglucose (2-DG) or glycolysis-inhibiting analogs thereof. The invention also provides pharmaceutical compositions of 2-DG or glycolysis-inhibiting analogs thereof for use in the methods of the invention. |
申请人 |
WISCONSIN ALUMNI RESEARCH FOUNDATION;HUTCHINSON, ELIZABETH, B.;MEYERAND, MARY, ELIZABETH;RUTECKI, PAUL, A.;SUTULA, THOMAS, P. |
发明人 |
HUTCHINSON, ELIZABETH, B.;MEYERAND, MARY, ELIZABETH;RUTECKI, PAUL, A.;SUTULA, THOMAS, P. |