发明名称 Novel salts as Anti-Inflammatory, Immunomodulatory and Anti-Proliferatory Agents
摘要 The present invention relates to a salt selected from the group comprising the N-methyl-D-glucamine salt (NMG), the diethylamine salt (DEA) salt, the magnesium salt, the tromethamine salt, the choline salt, the L-arginine salt, the zinc salt, and the 4-(2-hydroxyethyl)morpholine (HEM) salt of compounds of the general formula (I) wherein X is selected from the group consisting of CH2, S, or O; D is O or S; R8 is hydrogen or alkyl; E is an optionally substituted phenylene group; Y is a monocyclic or bicyclic substituted or unsubstituted 6-9 membered ring system which may contain one or more heteroatoms selected from N or S and which contains at least one aromatic ring; n is 0 or 1; and q is 0 or 1; with the proviso that compounds wherein X═CH2, q=0, Y=unsubstituted phenyl and E=unsubstituted phenylene are excluded; or a hydrate thereof.
申请公布号 US2012035175(A1) 申请公布日期 2012.02.09
申请号 US201113174900 申请日期 2011.07.01
申请人 AMMENDOLA ALDO;DIEDERICHS JULIA;LEBAN JOHANN;VITT DANIEL;4SC AG 发明人 AMMENDOLA ALDO;DIEDERICHS JULIA;LEBAN JOHANN;VITT DANIEL
分类号 A61K31/196;A61K31/341;A61K31/381;A61K31/4418;A61K31/5375;A61P1/00;A61P11/06;A61P17/06;A61P19/04;A61P25/00;A61P27/02;A61P29/00;A61P31/04;A61P31/12;A61P33/02;A61P35/00;A61P37/00;A61P37/06;C07C229/46;C07D213/64;C07D265/30;C07D307/30;C07D333/38;C07D333/60;C07D413/02 主分类号 A61K31/196
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