发明名称 |
New aptamer that specifically binds to human tau protein or its fragment, useful e.g. in vitro for isolating, purifying and/or detecting tau protein, and to treat cerebral infarction, pick disease and/or progressive supranuclear palsy |
摘要 |
Aptamer that specifically binds to human tau protein or its fragment, is new. Independent claims are included for: (1) kit comprising the aptamer; (2) a method for the purification of human tau protein or its fragments comprising contacting a sample containing human tau protein or its fragments with the aptamer and separating the obtained complex of aptamer and bound tau protein or its fragments from the remaining sample; and (3) a method for detection of human tau protein or its fragments comprising contacting a sample to be tested with the aptamer and detecting a binding event between the aptamer and the human tau protein or its fragment. - ACTIVITY : Cerebroprotective; Vasotropic; Neuroprotective; Nootropic; Antiparkinsonian. - MECHANISM OF ACTION : None given.
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申请公布号 |
DE102010038842(A1) |
申请公布日期 |
2012.02.09 |
申请号 |
DE20101038842 |
申请日期 |
2010.08.03 |
申请人 |
HELMHOLTZ-ZENTRUM FUER UMWELTFORSCHUNG GMBH - UFZ |
发明人 |
STOLTENBURG, REGINA;STREHLITZ, BEATE;REINEMANN, CHRISTINE |
分类号 |
C07H21/04;A61K31/711;A61P25/00;C07K1/22;C12N15/115;C12Q1/68;G01N33/48 |
主分类号 |
C07H21/04 |
代理机构 |
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地址 |
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