发明名称 NOVEL ARTEMISININ-LIKE DERIVATIVES WITH CYTOTOXIC AND ANTI-ANGIOGENIC PROPERTIES
摘要 The present invention relates to novel artemisinin-like derivates, and especially dihydroartemisinin derivates and pharmaceutical compositions comprising the present compounds. The present invention further relates to the use of the present compounds for the treatment of cancer, especially by oral administration. Especially, the present invention relates to dihydroartemisinin compounds (DHA) substituted by, through an ester linkage by a linear or branched C1 to C6 alkyl optionally substituted by one or more halogens. Especially preferred substituents are acetate, propionate, isopropionate, butyrate and isobutyrate,
申请公布号 CA2807263(A1) 申请公布日期 2012.02.09
申请号 CA20112807263 申请日期 2011.08.03
申请人 DAFRA PHARMA N.V. 发明人 JANSEN, FRANS HERWIG
分类号 C07D493/20;A61K31/357;A61P35/00 主分类号 C07D493/20
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