EXPRESSION OF ANTIBODY OR A FRAGMENT THEREOF IN LACTOBACILLUS

摘要

Described herein is a Lactobacillus comprising an exogenous nucleic acid sequence expressing an antibody or scFv fragment that binds to at least one of a host mammalâ s cell surface molecules so as to inhibit infection from a pathogen, and wherein the exogenous nucleic acid sequence is integrated into a chromosome of said Lactobacillus. The antibodies are preferably directed towards ICAM-1, CD18 or CD11, and the microorganism may be used in the treatment or prevention of HIV infection or rotavirus infection. Also provided are formulations and modes of administration of the Lactobacillus.