发明名称 |
FORMULATION FOR INDUCING BROADLY REACTIVE NEUTRALIZING ANTI-HIV ANTIBODIES |
摘要 |
<p>The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.</p> |
申请公布号 |
EP2413951(A2) |
申请公布日期 |
2012.02.08 |
申请号 |
EP20100759166 |
申请日期 |
2010.04.05 |
申请人 |
DUKE UNIVERSITY |
发明人 |
ALAM, S., MUNIR;HAYNES, BARTON, F.;SEKARAN, MOSES, D.;TOMARAS, GEORGIA;SHEN, XIAOYING |
分类号 |
A61K38/16;A61K38/08;A61K47/48;A61P31/12;A61P31/18 |
主分类号 |
A61K38/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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