| 摘要 |
FIELD: medicine. ^ SUBSTANCE: as a result of substitution of part of amino-acid sequence of human protein PRG-4 coded with exon 6 with artificial polypeptide, including 4-15 sequences KEPAPTT or KEPAPTT-like sequences, recombinant proteins are produced with considerably lower number of glycolised repetitions compared to natural lubricin, which at the same time preserve its lubricating properties. It is suggested to use new recombinant proteins in pharmaceutical compositions and in methods of treatment, where natural lubricin is traditionally used. ^ EFFECT: application of the present invention for medical purposes has certain advantages related to simplification, compared to native protein. ^ 28 cl, 1 dwg, 3 tbl, 9 ex |
