发明名称 |
CETP inhibitors |
摘要 |
Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis:
In the compounds of Formula I, B or R 2 is a phenyl group which has an ortho aryl, heterocyclic, benzoheterocyclic or benzocycloalkyl substituent, and one other position on the 5-membered ring has an aromatic, heterocyclic, cycloalkyl, benzoheterocyclic or benzocycloalkyl substituent connected directly to the ring or attached to the ring through a -CH 2 -. |
申请公布号 |
EP2415759(A1) |
申请公布日期 |
2012.02.08 |
申请号 |
EP20110184420 |
申请日期 |
2005.07.01 |
申请人 |
MERCK SHARP & DOHME CORPORATION |
发明人 |
ALI, AMJAD;NAPOLITANO, JOANN M.;DENG, QIAOLIN;LU, ZHIJIAN;SINCLAIR, PETER J.;TAYLOR, GAYLE E.;THOMPSON, CHRISTOPHER F.;QURAISHI, NAZIA;SMITH, CAMERON J.;HUNT, JULIANNE A.;DOWST, ADRIAN A;CHEN, YI-HENG;LI, HONG |
分类号 |
C07D207/26;A61K31/4015;A61P9/00;C07D207/27;C07D233/32;C07D263/20;C07D263/22;C07D263/24;C07D285/10;C07D401/04;C07D413/04;C07D413/06;C07D413/10;C07D417/04;C07D417/10 |
主分类号 |
C07D207/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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