Anti B7-H3 antibody

摘要

An antibody exhibiting antitumor activity that binds to B7-H3, a functional fragment of the antibody, a pharmaceutical composition that includes the antibody or the functional fragment, methods for making the antibody or the functional fragment, methods for treating a tumor using the antibody or the functional fragment, and polynucleotides encoding the antibody or the functional fragment.

主权项

1. An antibody characterized by having the following properties:
(a) specific binding to an IgC1 and/or IgC2 domain of B7-H3, (b) having a constant region that is a human constant region; (c) comprising CDRH1 consisting of an amino acid sequence comprising SEQ ID NO: 92, CDRH2 consisting of an amino acid sequence comprising SEQ ID NO: 93, and CDRH3 consisting of an amino acid sequence comprising SEQ ID NO: 94 as complementarity determining regions of the heavy chain and comprising CDRL1 consisting of an amino acid sequence comprising SEQ ID NO: 95, CDRL2 consisting of an amino acid sequence comprising SEQ ID NO: 96, and CDRL3 consisting of an amino acid sequence comprising SEQ ID NO: 97 as complementarity determining regions of the light chain; (d) having an antibody-dependent cell-mediated phagocytosis (ADCP) activity; and (e) having an in vivo antitumor activity against tumors expressing B7-H3 comprising SEQ ID NO: 6 or SEQ ID NO:10.