Implant devices that differ by release profile and methods of making and using same

摘要

Described herein are implant devices, kits comprising the implant devices, and methods of making and using the devices and kits. In one aspect, a plurality of implant devices comprises at least two implants that exhibit a different release profile of a bioactive agent. In another aspect, an implant device comprises one or more adjoined polymer bodies, wherein at least two of the polymer bodies provide a different release profile of a bioactive agent. In another aspect, a kit comprises one or more disclosed implant devices. In another aspect, methods of delivering a bioactive agent to a subject comprise administering to the subject one or more disclosed implant devices.

主权项

1. An implant device comprising a polymer body having at least two portions that each comprise a bioactive agent therein and/or on a surface thereof, the bioactive agent being releasable from the at least two adjoined portions, wherein a release profile characterizes the release of the bioactive agent from each of the portions and wherein at least two portions differ by release profile by releasing a different amount of the bioactive agent over time, provided that the portions are not adjoined only in a core-sheath configuration, and wherein the polymer body comprises at least two cross-sectional portions; wherein said implant device is in the form of a rod, where at least two cross-sectional portions having different release profiles are formed on one end of the rod; wherein the implant device has a cumulative release profile of the at least two portions and the at least two cross-sectional portions.