N.EPSILON. AND/OR N.ALPHA. DERIVATIZED, METAL AND ORGANIC PROTECTED L-HISTIDINE FOR COUPLING TO BIOMOLECULES FOR HIGHLY EFFICIENT LABELING WITH [M(OH2)3(CO)3]+ BY FAC COORDINATION

摘要

The present invention relates to novel histidine derivatives that can be used for the labeling of biomolecules with radioactive metal tricarbonyls. The new derivatives have a histidine that is derivatized at the N.epsilon. and at least protected at the N.alpha. and optionally at the N.delta. ; or derivatized at the N.alpha. and at least protected at the N.alpha. and optionally at the N.delta. ; or derivatized at the N.epsilon. and N.alpha. and at least protected at the N.alpha. and optionally at the N .delta.; or derivatized at the N.epsilon.; or derivatized at the N.alpha.; or derivatized at the N.epsilon. and N.alpha.; or at least protected at the N.alpha. and optionally at the N..delta..