发明名称 |
A MUTANT E. COLI STRAIN WITH INCREASED SUCCINIC ACID PRODUCTION |
摘要 |
A method for isolating succinic acid producing bacteria is provided comprising increasing the biomass of an organism which lacks the ability of catabolize pyruvate, and then subjecting the biomass to glucose-rich medium in an anaerobic environment to enable pyruvate-catabolizing mutants to grow. The invention also provides for a mutant that produces high amounts of succinic acid, which has been derived from a parent which lacked the genes for pyruvate formate lyase and lactate dehydrogenase, and which belongs to the E.coli Group of Bacteria. |
申请公布号 |
CA2236472(C) |
申请公布日期 |
2012.02.07 |
申请号 |
CA19962236472 |
申请日期 |
1996.10.31 |
申请人 |
THE UNIVERSITY OF CHICAGO |
发明人 |
DONNELLY, MARK;MILLARD, CYNTHIA S.;STOLS, LUCY |
分类号 |
C12N1/20;C12N15/09;C12N1/21;C12N1/38;C12N9/04;C12P7/40;C12P7/44;C12P7/46;C12R1/19;C12R1/225 |
主分类号 |
C12N1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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