发明名称 |
Processes for making hydrazides |
摘要 |
A method is disclosed for preparing hydrazides from hydrazine and an acyl chloride which comprises the steps of (a) preparing a stirred substantially uniform slurry comprising hydrazine and an inert solvent at low temperature; and (b) adding an acyl chloride continuously to said slurry. The method avoids or limits production of undesired bis-hydrazide by-products. The method is used to prepare 3-methyl-3-mercaptobutanoic acid hydrazide, a molecule used to link calicheamicin to a monoclonal antibody.
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申请公布号 |
US8110705(B2) |
申请公布日期 |
2012.02.07 |
申请号 |
US20080123777 |
申请日期 |
2008.05.20 |
申请人 |
CHIARELLO GEORGE ANELLO;SAHLI AYMAN;WYETH LLC |
发明人 |
CHIARELLO GEORGE ANELLO;SAHLI AYMAN |
分类号 |
C07C231/02;C07C241/04 |
主分类号 |
C07C231/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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