Lactam compounds and their use as pharmaceuticals

摘要

The present invention relates to inhibitors of 11-&bgr;hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-&bgr;hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.