CORTICOGENESIS OF HUMAN PLURIPOTENT CELLS

摘要

This invention relates to in vitro methods for the induction of corticogenesis in human pluripotent cells, such as iPS cells, by culturing the cells under conditions which stimulate retinoid signalling and inhibit TGFß superfamily signalling. This may be useful in production of cortical neurons, in particular patient- specific cortical neurons; the modelling of juvenile and adult-onset neurological diseases; and the development of therapeutics.