S1 PROTEASE C- TERMINAL POLYPEPTIDES AND USES THEREOF FOR TREATING INFLAMMATION OR COAGULATION DISORDERS

摘要

The present invention provides polypeptides comprising or consisting of an amino acid sequence from the C-terminal region of an S1 serine peptidase, or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant or derivative thereof, for use in the treatment or prevention of inflammation and/or excessive coagulation of the bllod. Related aspects of the invention provide isolated polypeptides comprising or consisting of any one of amino acid sequences SEQ ID NO: 1 or 113, or a fragment, variant, fusion or derivative thereof, or a fusion of said fragment, variant or derivative thereof, which exhibit an anti-inflammatory and/or anti-microbial and/or anti-coagulant activity, together with isolated nucleic acid molecules, vectors and host cells for making the same. Additionally provided are pharmaceutical compositions comprising a polypeptide of the invention, as well as methods of use of the same in the treatment and/or prevention of inflammation and/or excessive coagulation.