摘要 |
<p>Provided are methods and compositions for detecting a compound that activates a sirtuin deacetylase activity on a fluorescent-free activation substrate in vitro. Further provided are sirtuin modulating compounds of the formulas (I) - (XXI), and related compounds (XXXI), (XXXII), (XXXIII), and (XXXIV), including the fluorescent free- substrate SIRT1 activator compounds of formulas (XL), (XI), (XII), and (XIII).</p> |
申请人 |
SIRTRIS PHARMACEUTICALS, INC.;DAI, HAN;RIERA, THOMAS, V.;STEIN, ROSS, L.;SZCZEPANKIEWICZ, BRUCE |
发明人 |
DAI, HAN;RIERA, THOMAS, V.;STEIN, ROSS, L.;SZCZEPANKIEWICZ, BRUCE |