发明名称 |
BICYCLIC MGLUR5 POSITIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING SAME |
摘要 |
In one aspect, the invention relates to bicyclic mGluR5 positive allosteric modulators, for example 6-(phenylethynyl)-3,4-dihydroisoquinolin-1(2H)-one, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. |
申请公布号 |
US2012028955(A1) |
申请公布日期 |
2012.02.02 |
申请号 |
US201113269933 |
申请日期 |
2011.10.10 |
申请人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;WEAVER CHARLES DAVID;RODRIGUEZ ALICE L.;NISWENDER COLLEEN M.;JONES CARRIE K.;WILLIAMS RICHARD |
发明人 |
CONN P. JEFFREY;LINDSLEY CRAIG W.;WEAVER CHARLES DAVID;RODRIGUEZ ALICE L.;NISWENDER COLLEEN M.;JONES CARRIE K.;WILLIAMS RICHARD |
分类号 |
A61K31/472;A61K31/4035;A61K31/4725;A61K31/496;A61K31/5377;A61P3/04;A61P3/10;A61P25/00;A61P25/06;A61P25/08;A61P25/14;A61P25/18;A61P25/24;A61P25/28;A61P25/30;C07D209/46;C07D209/48;C07D217/24;C07D401/06;C07D413/06 |
主分类号 |
A61K31/472 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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