Pyridinyl derivatives as inhibitors of enzyme nicotinamide phosphoribosyltransferase

摘要

The present application discloses a compound of the formula (I) wherein Q is optionally substituted pyridyl; p is 0-6; Y is formulae (i), (ii) and (iii) where X is =O, =S and =N-CN, r is 1-12, R is -Z-A, Z is a single bond, -S(=O)-, >P=O, >C=O, -C(=O)NH-, and -C(=S)NH-; and A is hydrogen, C-alkyl, C-cycloalkyl, - [CHCHO]-(C-alkyl), C-alkenyl, aryl, heterocyclyl, and heteroaryl; B is a single bond, -NR-, -S(=O)- and -O-; wherein R is selected from hydrogen, C-alkyl, C-cycloalkyl, -[CHCHO]-(C-alkyl), C-alkenyl, aryl, heterocyclyl, and heteroaryl; s is 0-6; and Cy is aryl, cycloalkyl, heterocyclyl, and heteroaryl. The compounds are usefuld for use as a medicament for the treatment of a disease or a condition caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPRT).