发明名称 |
METHOD AND MEANS FOR CURING OSTEOARTHRITIS |
摘要 |
<P>PROBLEM TO BE SOLVED: To provide a method for identifying a compound for guiding an assimilation stimulant action of chondrocytic cells. <P>SOLUTION: The method includes steps of: bringing the compound into contact with polypeptide containing an amino acid sequence to be selected from a group consisting of sequence numbers 58 and 59; and measuring characteristics of compound-polypeptide relevant to the assimilation stimulant action of the chondrocytic cells. In the method, the characteristics include coupling affinities of the compound to the polypeptide, and activation of a biological path for producing a biochemical marker to be an index of the assimilation stimulant action of the chondrocytic cells. <P>COPYRIGHT: (C)2012,JPO&INPIT |
申请公布号 |
JP2012021995(A) |
申请公布日期 |
2012.02.02 |
申请号 |
JP20110171061 |
申请日期 |
2011.08.04 |
申请人 |
GALAPAGOS NV |
发明人 |
NICK VANDEGINSTE;PETER HELWIG MARIA TOME;FRITZ MICHAEL;LIBIN MA;BRANDINI MILLERET BAKEL;HELMS HG VERNEST |
分类号 |
G01N33/50;A61K38/17;C12N15/09;C12N15/11;C12Q1/02;C12Q1/68;G01N33/15;G01N33/566;G01N33/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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